Gold And Silver Collection

Bar Round

what is the best procedure for drilling a 5mm dia through hole in a10mm dia round bar 100mm long, mild steel.?

Quantity-10k/day. please suggest feed,drill rpm.What type of drill to be used, is it possible on a vertical drilling machine?

Hi

You are going to need a very special machine for this sort of work. You will need something in the line of a multi spindle machine. With a six station machine you can drill the stock as a peck drill in the first four positions, cut off in the fifth, and feed in the sixth.

http://www.youtube.com/watch?v=HUGh0CoanDo&feature=related

You might also want to look into buying seamless tubing with the right diameter and through hole. Then the only operations that you would have would be cut-off and deburr.

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15 Copper Round Bar Sink with Flower Design    US $136.13

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125CT ROUND DIAMOND ETERNITY BAND 14K WHITE GOLD BAR    US $1,119.00

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^ LOT 5 X 999 FINE SILVER BARS ROUNDS A    US $15.55

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Bar Victorian

i am selling the contents of a restaurant loaded with antiques and a bar -what's the best way to find a buyer?

the bar is 20' long...great victorian american. there are incerdible 600 pound antique light fixtures, etc...too big for me to move or list on ebay? any advice? is there a website where i could find people that NEED things? like a "THINGS WANTED" website?

I do suggest ebay. I recently sold a vintage solid oak bar on ebay which was 16+ feet long. The guy traveled over 400 miles one way just to pick it up. You just have to say pick up only for the larger, heavy stuff (or if you have a truck and a strong back, offer delivery for a charge within a certain mile radius). Mind you, not everything always sells...but it's a good start because ebay reaches so many people for the price that you pay to list and sell.
Another way to go is have a big sale at the location where everything is located. I've done this also. The key is advertising what you have. The word antiques draws in a lot of people. Restaurant equipment is a good draw too.
I personally think that listing on various websites can be a waste of time. The chances of people finding your ad is low. One other idea that I've never actually tried (because I tend not to trust people) is to find a local (trustworthy/reputable) auction house that deals with antiques or antique shop and see if they can sell the items for you for a commision. These people often know of buyers from all over. If you choose that route...first make a list of everything that you have and try to research their worth so that you can get a fair price. An auctioneers usual commision is 20%-30%.
Good luck to you!

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ANTIQUE GOLD FILLED VICTORIAN BAR PIN BROOCH    US $9.95

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Gram Pure

how much would One Gram of pure gold usally cost ,i know it vaires?

Gold is traded daily on the New York Mercantile Exchange (comex). As of May 26 the closing price was $958.50 per oz. Converting to grams that would be $33.81 per gram.

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1 GRAM 999 PURE SILVER BAR EAGLE UNC NICE    US $2.49

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Heart Bar

Can the amount of caffine in one soda and one chocolate bar have any effect on the heart?

Yes, they are both packed with caffeine.

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5 Pure COPPER Rose on Heart Bars 1g 999 Fine Copper    US $2.99

Silver Chain Bracelet with Heart and T Bar Closure    US $6.00

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KA BAR 9157 US Navy 75th Purple Heart Comm NEW    US $60.85

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Pure Silver Rose on Heart Bar 1g NEW 2010 Bar    US $.99

14g 3 8 Heart Belly Navel Button Ring Bar Body Piercing    US $15.85

14g 3 8 Belly Button Navel Ring Ear Bar Heart Gems N6KD    US $12.90

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Gram Pamp

Tlr6- Cluster of Differentiation 286

Toll-like receptor 6 (TLR6) often designated as CD286 (cluster of differentiation 286), is a member of the Toll-like receptor family, a highly conserved series of ancient innate immune pattern recognition receptors. TLR6 was first described by Takeuchi et al in 1999 as a 91.9-kDa, 796 amino-acid polypeptide. The gene for TLR6 has been mapped to human chromosome 4p13. It has a single exon, and contains an N-terminal signal peptide, 20 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain homologous to interleukin-1 receptor (IL1R), similar to other TLRs (1). TLR6 is most closely related to TLR1, TLR10, and TLR2 with 68%, 46%, and 31% overall AA sequence identity, respectively. (2)

In vivo, TLR6 transcript is observed in thymus, spleen, and lung. TLR6 mRNA expression is highest in B cells and monocytes. In vitro, TLR6 mRNA expression is upregulated in THP-1 cells upon PMA-induced differentiation. Further, TLR6 is moderately upregulated by autocrine IFN-?, IL-1?. However, TLR6 mRNA expression in THP-1 cells is unaffected by exposure to both Gram-positive and Gram-negative bacteria. Ex vivo, monocyte and, in particular, granulocyte TLR6 expression is down-regulated upon exposure to Gram-negative bacteria. (3, 4, 5).

Coexpression of TLR2 and TLR6 at the cell surface is crucial for recognition of diacylated lipopeptide and peptidoglycan and subsequent cellular activation in human cells. TLR6 was expressed, although at a lower level than TLR2, on the cell surface in monocytes, monocyte-derived iDCs, and neutrophils, but not on B, T, or NK cells. Confocal microscopic analysis revealed that TLR6 was colocalized with TLR2 at the plasma membrane of monocytes (6). Like TLR1, TLR6 is thought to specify or enhance the pathogen-associated molecular patterns (PAMP) sensitivity of TLR2 and contribute to its signaling capabilities through heterodimerization. TLR2/6 heterodimers recognize diacyl lipopeptides such as MALP2 (the Mycoplasma-derived macrophage-activating lipopeptide 2). CD14 was reported to enhance the responses of TLR2/TLR6 complexes to their ligands. CD36 helps TLR2/6 to further discriminate among their ligands because it contributes to the response to MALP2 and lipoteichoic acid (from gram-positive bacteria), but not to zymosan. Upon ligand recognition, TLR2/TLR6 complexes recruit both the sorting adaptor TIRAP and the signaling adaptor MyD88, and initiate the MyD88-dependent pathway, activating the transcription factors nuclear factor (NF)-?B and activator protein-1 (AP-1), leading to inflammatory cytokine production. (7)

Reference:

1. K Tantisira Genes and Immunity (2004) 5, 343–346.

2. O. Takeuchi Gene (1999) Volume 231, Issues 1-2, 29,pp 59-65

3. Takeuchi, O. et al. (1999) Gene 231:59.

4. Zarember, K.A. & P.J. Godowski (2002) J. Immunol. 168:554.

5. Hornung, V. et al. (2002) J. Immunol. 168:4531.

6. Yoshiya Nakao (2005) The Journal of Immunology, 174: 1566-1573.

7. Myeong Sup Lee (2007) Annual Review of Biochemistry Vol. 76: 447-480.

About the Author

IMGENEX India Pvt Ltd. the only biotech company in Orissa and one of its kinds in Eastern India. IMGENEX India started in Oct as an outsourcing branch of IMGENEX Corporation, San Diego, USA. Find out more information about Toll-like receptors .

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